There's room. Corporate ego at Comcast-NBC-Universal-Sheinhardt Wig Company probably would have them balk at the idea of the peacock on a sub-channel. Even in market 144.
The peacock is on some subchannels:
http://en.wikipedia.org/wiki/Category:NBC_subchannel-only_network_affiliates
I believe NBC, prior to Comcast ownership, was respecting Hearst's claim into that region, as WBAL was the defacto NBC affiliate and carried in HD on all Salisbury DMA cable systems. In exchange for that, Hearst kept NBC, lower rated than ABC, for several years although now ABC is just as weak, but NBC on the primary signal in certain markets like Monterey, CA.
The Comcast now is much bigger than NBC, so could care less about relationships like that. It's not going to sacrifice here for there.
And, there has been loss of network availability with satellite carrying Salisbury MD stations and not being able to provide an NBC affiliate in some situations - I believe with Dish Network. This resolves this problem as Dish Network has a local NBC affiliate to pull from to offer.
As far as cable/Fios, this station will obviously be carried in HD. I'd guess cable/Fios won't be having 3 NBCs carried. Maybe WBAL only in SD in Maryland, and WCAU only in SD in Sussex Co., while this new affiliate is on HD and SD, throughout Salisbury Nielsen DMA cable and satellite. I'd think the SD feed will also be in Kent County, DE. I don't think Comcast/NBC will permit it into New Castle County at all, however, even though its Delaware only network affiliate and Delaware is such as small state.
If Delaware had it's primary early like New Hampshire and was a swing state, there could be election money made with a state wide Delaware TV network NBC station, justifying Comcast/NBC to even buy out this station for that.