Is anyone out there airing any Skpe audio, while sending phone calls back to the Skpe program/person? Right off the top of my head, this sounds like a mix-minus nightmare, but you know how radio station Sales Departments are.
I have not done this but if you have an air console with at least 3 outputs it should not be difficult. Just set it up with a decent sound card installed in the PC and in the same way you would do any other phone system.
I suppose this is in addition to the Skype guest utilizing some type of mixer to mix in studio audio (including phone calls) with himself/herself. It sounds like this has the potential to be a latency nightmare. Is it possible when airing phone calls, for those same calls to be delayed when feeding that audio to the Skype talent? I'm wondering why whenever I see a Skype person on TV, I never see any earphone monitoring (unless it's all wireless, so the TV viewers can't see it).