I tried to adapt to living in a market of less than 100,000 some years ago. Even if just a part-time home, I just found it too different for me and left in just a few years. I can see someone who truly likes that and would hate a bigger city.
Anything bigger then about 25-30,000 is too big for me and thats even pushing it.
2000 people in a nice town in Nebraska was perfect, as lower 48 towns go.