South Carolina has a lot of these. ETV started with the legacies in Charleston, Columbia and Greenville (Channels 7, 35 and 29 respectively), but then they added several stations.
WHMC TV and FM in Conway serves the Myrtle Beach area, and that signed on back when Conway was a small town outside Myrtle Beach.
You have Sumter, with less than 50,000 and a TV and FM, but that area has a lot of importance.
Tiny Allendale, a town of under 4,000, got a station in the late 1960s, but that station is the one that serves highly-populated Aiken and Augusta.