I told ya Friends would be leaving!! It's run its course, years ago plenty of Fox/WB/UPN's aired Friends reruns in prime access. Now with 20 reruns a day on TBS and most OTA affiliates dumping it to late night or even graveyard, not worth it anymore. A great syndication run concludes for a great sitcom. OTOH, Seinfeld is here to stay for at least a few more years in syndication. Hot in Cleveland did very poor in the syndication ratings, in fact KCYU ran them at 12:35AM and 6:30AM, and had never given them an afternoon/early evening slot.
The Middle, while STILL in production, also has done poorly in syndication compared to ABC's other sitcom giant, Modern Family. The stations tried to run it in prime access and good hours early on but the ratings didn't catch on. A lot of stations dumped it to overnight, some even past 2AM. On the weekend drama side, Grey's Anatomy had the same poor result in syndication while ABC still keeps renewing it on Thursdays.