When I had my VHF/UHF combo antenna up, I would often see KTCA from Minneapolis on channel 2.
Now it's a bit rarer, but still comes in fairly often, at least in the summer.
I've also seen KGAN Cedar Rapids (at least tentatively), WBAY Green Bay, and the Thunder Bay, ON station, but all of those are extremely rare.
As for Es...I've made 28 Es loggings on Ch 2, which is probably less than most serious Midwest DX'ers (I hope to improve my totals next year, especially on ch4 and 5 where I'm SORELY lacking!). The most common is KPRC. Some of them (going from NW to NE) include CKAL-TV-1 Lethbridge, KTVQ Billings, KWGN Denver, KTVN Reno, KNAZ Flagstaff, KASA Santa Fe, KMID Midland, WBRZ Baton Rouge (common), WDIQ Dozier (common), WSB Atlanta, WCBD Charleston, WUND Dozier, KDKA Pittsburgh, WCBS New York, WGBH Boston, CFAP Quebec, and WLBZ Bangor.