For me in Gary, IN, it's actually 2 stations, WCPX on RF 43 (Ion) & WLS-TV on RF 44 (ABC) for full power stations. I never had problems with WCPX in the months after 6/12/2009, until WLS-TV decided to change their RF channel from 7 to 44. I never got WLS-TV that well on RF 52, but when they returned to RF 7, I never had problems. Once they started operating on RF 44 from the Sears Tower, RF 43 received interference from RF 44 the entire time. RF 44 would always pixelate. Before the final antenna was installed on the Sears Tower, the first new antenna didn't reach those within 10 miles of the Sears Tower, while for me, the signal dropped out constantly. When WLS-TV operated RF 44 from the John Hancock, I had fewer problems, & WCPX received no interference. ABC has always insisted on operating from the Sears Tower over the John Hancock. Now with their new antenna installed, & RF 7 turned off, the bugs are still not worked out, & it seems complaints are mostly coming from the far suburbs & Indiana that have trouble with the signal, & I still have problems with WCPX getting interference from WLS-TV to this day. Somehow, WLS-TV doesn't affect WSNS on RF 45.
When it comes to LPTV, the overall worst is WOCK-CD on RF 4, mainly because they transmit at only 300 watts, & almost no one gets the station. I can only get it from Gary, IN, if I use an outdoor antenna optimized for RF channels 2 - 13 (I use an Antennacraft CS600), & a pre-amp, & reception is iffy on some days. Being on VHF Lo is also a major problem, as outdoor antennas optimized for VHF (old-fashioned element antennas) are the only way to get VHF-Lo. On the UHF side for LPTV, WWME-LD is iffy on some days, because the station is nulled toward Indiana, mainly to protect sister station in South Bend, IN, WMYS-LD (both RF 39). WWME-LD carries MeTV on the main channel, & I can get that on WCIU 26.3 (RF 27), but I must get WWME-LD in order to watch Bounce on VC 23.2. I've also changed antennas more than once. I originally used a combo VHF/UHF/FM antenna, but that antenna was falling apart. I went with an Antennacraft CS600 antenna, & been used all this time for VHF. For UHF I originally used a Winegard HD9032 yagi antenna, & only worked with the full power stations, & WWME-LD, but didn't work as well with WCPX on RF 43 or WLS-TV on RF 44. Since switching to an Antennas Direct DB8 whisker antenna, I get less interference from WCPX & WLS-TV (I believe the problem lies with WLS-TV engineering problems that doesn't keep interference to a minimum), but since the DB8 is a lot less directional, I started getting other LPTV stations that are normally too weak to receive on the Indiana side, due to the signals aiming their signals more at the nearby south suburbs, or nearby western suburbs (a few can also aim their signal to the northern suburbs).