You just won the "nonstop sentence of the week" award.
Is your point that the show could be moved to another city? It would have to be one where guests are accessible.
Or do you mean that the show can be done in a "virtual studio" from the cheapest location possible? Would this preserve the "one on one" feel of the host and their guests?
And unless we see some accounting numbers for the show, we don't know what the major costs are. Obviously, the host and staff are a big part. Do guests have transportation and lodging paid for? What is the difference in technical staff NYC union rates vs. let's say, LA?
Having had at least a "sidebar" part in the move of a TV and radio operation off Manhattan to New Jersey, I know the costs in The City are horrendous. Even things like key staff parking are very much in the outrageous range.