On the low end AS card (5111, if I remember the number right) I can hear a difference between input and output quality when recording, that I don't hear on the comparable Digigram card. Can't say I can tell much difference between the cards on digital playback (e.g., from a ripped cut off a commercial CD).
So my production computers have Digigram cards.
On the other hand, some popular automation software, e.g., Simian, is designed to work with the AS mixing software, making it a logical choice over the Digigram cards for those uses.