"Pensacola: Wings Of Gold" was syndicated and starred James Brolin
and Kathryn Morris (in her case, for the first season, 1997-98).
Not too far from Pensacola is New Orleans and I can think of three shows
that took place there: "Bourbon Street Beat," "Longstreet," and "Frank's
Place."
Also, David Victor had three shows on ABC in the early '70s; "Marcus Welby,
M.D." took place in Santa Monica; "Owen Marshall, Counselor At Law" in Santa
Barbara; and Anthony Quinn's "The Man And The City" in Albuquerque.
And believe it or not, in the '50s there was a show that actually took place
in Atlanta (almost unheard-of for a show to take place outside New York or
LA in those days): "This Is Alice," a syndicated sitcom about a female Dennis
the Menace. If for no other reason, it deserves a minor place in TV history
because Phyllis Coates (the first Lois Lane in the George Reeves "Superman"
episodes) played Mrs. Holliday (Alice's mother?). (Interesting, too, that Ms.
Coates' two other series were also sitcoms: "The Duke," about a professional
boxer (not her, obviously, although she could pack a mean punch against some
of the baddies on "Superman") in 1954; and "Professional Father" as a nurse
in 1955.)