There's a lot of shows that haven't aired in the Des Moines market for awhile. Here's some that I can think of :
The Wendy Williams Show - previously on WHO 13 (NBC) but hasn't aired for awhile I can't remember the last time. I know the shows cancelled but I brought it up as Sheri was a replacement for this show and Sheri also does not air on any of the local channels. Only way you can watch it is if you get the over the air channel Bounce at 5am and it's a day behind.
Access Hollywood - this show use to air on WHO and KCCI before disappearing but it hasn't been on for awhile either. Plus Access Hollywood Live has never aired in Des Moines since it launched in 2010.
TMZ Live - This show has never aired since it launched in 2013.
Celebrity Page - Does not air.
Highway Thru Hell - this show also does not air in Des Moines.
The Song, Top 10, Made in Hollywood, Bloodline Detectives, Ring Nation, Heartland, and Murdoch Mysteries also don't air.
Reruns of The Rookie also don't air on Weekends and Missing hasn't aired on weekends for awhile last time airing on KDSM. Last time I actually remember seeing it on TV was around 2009.